Article: biomarker for ME might be found in the gut biome

This article from Cornell Chronicle summarizes recent findings published in the journal, Microbiome, reporting that researchers could predict whether a person has ME based on the diversity of their microbiome, using stool samples.

"The researchers sequenced regions of microbial DNA from the stool samples to identify different types of bacteria. Overall, the diversity of types of bacteria was greatly reduced and there were fewer bacterial species known to be anti-inflammatory in ME/CFS patients compared with healthy people, an observation also seen in people with Crohn’s disease and ulcerative colitis. 

At the same time, the researchers discovered specific markers of inflammation in the blood, likely due to a leaky gut from intestinal problems that allow bacteria to enter the blood, Giloteaux said. Bacteria in the blood will trigger an immune response, which could worsen symptoms."

These might not be the most revolutionary findings, especially regarding the lack of diversity in gut bacteria (first quoted paragraph above), but I had never heard that it was, specifically, bacteria, that leaks into the bloodstream in leaky gut syndrome (second quoted paragraph).  The leaked substance has usually been described more generally as "particles" or "toxins" leaking into the bloodstream, not necessarily bacteria.  Could this be a significant finding?

Still, the articles doesn't address some obvious questions.  What is the connection between the lack of diversity in the gut biome and the leaky gut condition which allows some of those non-diverse bacteria to enter the bloodstream?  And what are the "specific markers of inflammation in the blood" the article references? Unfortunately, we would have to access the original publication in Microbiome to find out.